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Anti Gα13 Rabbit Polyclonal Antibody

价格2600.00
品牌NewEastBio   
产地美国
货号21005
免疫原Rabbit
规格100μl
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  • 概述

    Gα13 [21005]
    [100 µL]


    Catalog Number:  21005
    Gene Symbol:  Ga13
    Description:   Anti Gα13 Rabbit Polyclonal Antibody
    Background:   Heterotrimeric G proteins are essential cellular signal transducers. Gα13 is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Gα13 are being explored.
    Immunogen:   Recombinant full length Gα13 protein
    Applications:   ELISA, WB, IHC
    Recommended Dilutions:   
    ELISA 1:100-1:5000
    WB 1:100-1:2000
    IHC 1:50-1:100
    Concentration:   1 mg/ml
    Host:   Rabbit
    Format:   Liquid
    Clonality:   Polyclonal
    Isotype:   
    Purity:   Purified from serum
    Storage buffer:
    Preservative:  no
    Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
    Species Reactivity:  13 polyclonal antibody recognizes Gα13 of vertebrates.
    Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles
    Download Datasheet:  
    Western blot:  
    Western blot analysis of Gα13 proteins. MEF whole-cell lysates were used for western blot with anti Gα13polyclonal antibody (Cat. # 21005).
    Immunofluorescence:  
    Immunofluorescence of mouse embryonic fibroblast (MEF) cells. Wild-type MEF cells (top panel) and Gα13 double knock-out cells (Gα13 -/-, bottom panel) were fixed and stained with anti-Gα13 polyclonal antibody (Cat. # 21005). Arrows indicate the dorsal ruffle strcture of one cell.


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    Publications:
    1.  Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization
        J Biol Chem. 2011 Sep 2;286(35):31055-61
    2.  Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Galpha and beta-arrestin-2
        Br J Pharmacol. 2011 Feb;162(3):733-48
    3.  Gα12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation
        Carcinogenesis (2010)
    4.  Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency
        J Biol Chem. 2009 Oct 2;284(40):27409-15


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